Burckhardt was born in Lausanne, Switzerland, and studied in Leipzig and Gottingen. In 1809 his proposal to launch an expedition to the source of the Niger was accepted by the African Association. He studied Arabic at Cambridge, to prepare himself for the journey, and furthered his knowledge of the language in Aleppo, Syria.
In the end, he never made the journey up the Niger - dysentery killed him just days before his caravan was due to depart from Cairo. But his travels in the Levant and Egypt, meticulously documented in his letters and journals, and his several books, advanced Western knowledge of the area. In particular, he is celebrated as the man who discovered the ruins of Petra.